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A cup of tea tastes completely different out of a ceramic mug, than it does a plastic one.
A cup of tea tastes completely different out of a ceramic mug, than it does a plastic one.
Then take the entire pot, and pour it’s straight in the bin.
Fanny milk, not available in the UK.
Dude, we’re on Lemmy. Jump to conclusions or GTFO.
They’re in your bum, aren’t they?
I’m going with Australia
Farts are funny, that is a universal constant.
Pro tip: get a small folding stool to place your feet on. Straightens out the old poo pipe
That’s a funny way to spell Stoke.
You’re not the Reddit 2-dicks guy, are you?
Abstract
High protein intake is common in western societies and is often promoted as part of a healthy lifestyle; however, amino-acid-mediated mammalian target of rapamycin (mTOR) signalling in macrophages has been implicated in the pathogenesis of ischaemic cardiovascular disease. In a series of clinical studies on male and female participants (NCT03946774 and NCT03994367) that involved graded amounts of protein ingestion together with detailed plasma amino acid analysis and human monocyte/macrophage experiments, we identify leucine as the key activator of mTOR signalling in macrophages. We describe a threshold effect of high protein intake and circulating leucine on monocytes/macrophages wherein only protein in excess of ∼25 g per meal induces mTOR activation and functional effects. By designing specific diets modified in protein and leucine content representative of the intake in the general population, we confirm this threshold effect in mouse models and find ingestion of protein in excess of ∼22% of dietary energy requirements drives atherosclerosis in male mice. These data demonstrate a mechanistic basis for the adverse impact of excessive dietary protein on cardiovascular risk.
I bet they are all bots.
Or OneDrive.
File > Save As > Desktop.
Doesn’t save to local Desktop, but the OneDrive desktop wherever the fuck that is.
Drinks are served in jars, and your fries, well, you get 8 fries in a rusty old can.
Dude, based on an average stride length of 5ft, 50000 steps works out to over 47 miles.
That’s some long ass running.
One is a colossal shit hole. The other is a colossal shit hole in the sun.