You would need to run the LLM on the system that has the GPU (your main PC). The front-end (typically a WebUI) could run in a docker container and make API calls to your LLM system. Unfortunately that requires the model to always be loaded in the VRAM on your main PC, severely reducing what you can do with that computer, GPU-wise.
Just curious if you had a reference for this statement since it seems to be false in multiple ways.